PDF DatasheetHuman DNA-directed RNA polymerase III subunit RPC3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA-directed RNA polymerase III subunit RPC3 based upon sequence from: Human
Host: QP8107 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA-directed RNA polymerase III subunit RPC3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8107.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln534
Amino Acid Sequence: MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA IVSAVANRMD QTSSEIVRTM LRMSEITTSS SAPFTQPLSS NEIFRSLPVG YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALASLATATL ESVVQERFGS RCARIFRLVL QKKHIEQKQV EDFAMIPAKE AKDMLYKMLS ENFMSLQEIP KTPDHAPSRT FYLYTVNILS AARMLLHRCY KSIANLIERR QFETKENKRL LEKSQRVEAI IASMQATGAE EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ASEIQVDETI FLLESYIECT MKRQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DNA-directed RNA polymerase III subunit RPC3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA-directed RNA polymerase III subunit RPC3 Protein General Information | |
|---|---|
| Alternate Names | |
| RPC3; RPC62 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | POLR3C |
| Entrez Gene ID | 10623 |
| Ensemble Gene ID | ENSG00000186141 |
| RefSeq Protein Accession(s) | NP_001290385.1 |
| RefSeq mRNA Accession(s) | NM_001303456.1, NM_006468.7 |
| UniProt ID(s) | Q9BUI4 |
| UniGene ID(s) | Hs.515768 |
| HGNC ID(s) | HGNC:30076 |
| COSMIC ID Link(s) | POLR3C |
| KEGG Gene ID(s) | hsa:10623 |
| PharmGKB ID(s) | PA134870963 |
| General Description of Recombinant Human DNA-directed RNA polymerase III subunit RPC3 Protein. | |
| DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other mbers of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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