PDF DatasheetHuman Nuclear distribution protein nudE-like 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Nuclear distribution protein nudE-like 1 based upon sequence from: Human
Host: QP8111 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Nuclear distribution protein nudE-like 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8111.
Bioactivity Data: Untested
Full Length? Full Length of BC026101
Amino Acid Sequence: MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF QEGSRELEAE LEAQLVQAEQ RNRDLQADNQ RLKYEVEALK EKLEHQYAQS YKQVSVLEDD LSQTRAIKEQ LHKYVRELEQ ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE LAVRERQQEV TRKSAPSSPT LDCEKMDSAV QASLSLPATP VGKGTENTFP SPKAIPNGFG TSPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYISGN VNCGVLNGNG TKFSRSGHTS FFDKGAVNGF DTAPPPPGLG SSRPSSAPGM LPLSV
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Nuclear distribution protein nudE-like 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Nuclear distribution protein nudE-like 1 Protein General Information | |
|---|---|
| Alternate Names | |
| NDE2; EOPA; NUDEL; MITAP1; NDE1L1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NDEL1 |
| Entrez Gene ID | 81565 |
| Ensemble Gene ID | ENSG00000166579 |
| RefSeq Protein Accession(s) | NP_001020750.1 |
| RefSeq mRNA Accession(s) | NM_001025579.2, NM_030808.4, XM_017025185.1, XM_017025187.1 |
| UniProt ID(s) | Q9GZM8 |
| UniGene ID(s) | Hs.372123 |
| HGNC ID(s) | HGNC:17620 |
| COSMIC ID Link(s) | NDEL1 |
| KEGG Gene ID(s) | hsa:81565 |
| PharmGKB ID(s) | PA134887314 |
| General Description of Recombinant Human Nuclear distribution protein nudE-like 1 Protein. | |
| Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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