PDF DatasheetHuman MOB kinase activator 1A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MOB kinase activator 1A based upon sequence from: Human
Host: QP8113 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MOB kinase activator 1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8113.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Arg216
Amino Acid Sequence: SFLFSSRSSK TFKPKKNIPE GSHQYELLKH AEATLGSGNL RQAVMLPEGE DLNEWIAVNT VDFFNQINML YGTITEFCTE ASCPVMSAGP RYEYHWADGT NIKKPIKCSA PKYIDYLMTW VQDQLDDETL FPSKIGVPFP KNFMSVAKTI LKRLFRVYAH IYHQHFDSVM QLQEEAHLNT SFKHFIFFVQ EFNLIDRREL APLQELIEKL GSKDR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human MOB kinase activator 1A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MOB kinase activator 1A Protein General Information | |
|---|---|
| Alternate Names | |
| MOB1; MOBKL1B; MOBK1B; MATS1; C2orf6; Mob4B | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MOB1A |
| Entrez Gene ID | 55233 |
| Ensemble Gene ID | ENSG00000114978 |
| RefSeq Protein Accession(s) | NP_001304039.1 |
| RefSeq mRNA Accession(s) | NM_001317110.1, NM_001317111.1, NM_001317112.1, NM_018221.4 |
| UniProt ID(s) | Q9H8S9 |
| UniGene ID(s) | Hs.602092 |
| HGNC ID(s) | HGNC:16015 |
| COSMIC ID Link(s) | MOB1A |
| KEGG Gene ID(s) | hsa:55233 |
| PharmGKB ID(s) | PA25894 |
| General Description of Recombinant Human MOB kinase activator 1A Protein. | |
| Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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