PDF DatasheetHuman Phylloquinone omega-hydroxylase CYP4F11 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Phylloquinone omega-hydroxylase CYP4F11 based upon sequence from: Human
Host: QP8115 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Phylloquinone omega-hydroxylase CYP4F11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8115.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Thr38 – Gln524
Amino Acid Sequence: TYTFYDNCRR LQCFPQPPKQ NWFWGHQGLV TPTEEGMKTL TQLVTTYPQG FKLWLGPTFP LLILCHPDII RPITSASAAV APKDMIFYGF LKPWLGDGLL LSGGDKWSRH RRMLTPAFHF NILKPYMKIF NKSVNIMHDK WQRLASEGSA RLDMFEHISL MTLDSLQKCV FSFESNCQEK PSEYIAAILE LSAFVEKRNQ QILLHTDFLY YLTPDGQRFR RACHLVHDFT DAVIQERRCT LPTQGIDDFL KNKAKSKTLD FIDVLLLSKD EDGKELSDED IRAEADTFMF EGHDTTASGL SWVLYHLAKH PEYQEQCRQE VQELLKDREP IEIEWDDLAQ LPFLTMCIKE SLRLHPPVPV ISRCCTQDFV LPDGRVIPKG IVCLINIIGI HYNPTVWPDP EVYDPFRFDQ ENIKERSPLA FIPFSAGPRN CIGQAFAMAE MKVVLALTLL HFRILPTHTE PRRKPELILR AEGGLWLRVE PLGANSQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Phylloquinone omega-hydroxylase CYP4F11 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Phylloquinone omega-hydroxylase CYP4F11 Protein General Information | |
|---|---|
| Alternate Names | |
| CYPIVF11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CYP4F11 |
| Entrez Gene ID | 57834 |
| Ensemble Gene ID | ENSG00000171903 |
| RefSeq Protein Accession(s) | NP_001122404.1 |
| RefSeq mRNA Accession(s) | NM_001128932.1, NM_021187.3 |
| UniProt ID(s) | Q9HBI6 |
| UniGene ID(s) | Hs.187393 |
| HGNC ID(s) | HGNC:13265 |
| COSMIC ID Link(s) | CYP4F11 |
| KEGG Gene ID(s) | hsa:57834 |
| PharmGKB ID(s) | PA27120 |
| General Description of Recombinant Human Phylloquinone omega-hydroxylase CYP4F11 Protein. | |
| Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation . Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate . Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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