PDF DatasheetHuman Trichoplein keratin filament-binding protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Trichoplein keratin filament-binding protein based upon sequence from: Human
Host: QP8130 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Trichoplein keratin filament-binding protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8130.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn498
Amino Acid Sequence: MALPTLPSYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK QAEWSSKTSY QRSMHAYQRE KMKEEKRRSL EARREKLRQL MQEEQDLLAR ELEELRLSMN LQERRIREQH GKLKSAKEEQ RKLIAEQLLY EHWKKNNPKL REMELDLHQK HVVNSWEMQK EEKKQQEATA EQENKRYENE YERARREALE RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE QENLLKQRWE LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLSRRTQQIQ EELEADRRIL QALLEKEDES QRLHLARREQ VMADVAWMKQ AIEEQLQLER AREAELQMLL REEAKEMWEK REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE SLKHREQLIR NLEEVRELAR REKEESEKLK SARKQELEAQ VAERRLQAWE ADQQEEEEEE EARRVEQLSD ALLQQEAETM AEQGYRPKPY GHPKIAWN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Trichoplein keratin filament-binding protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Trichoplein keratin filament-binding protein Protein General Information | |
|---|---|
| Alternate Names | |
| TpMs | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TCHP |
| Entrez Gene ID | 84260 |
| Ensemble Gene ID | ENSG00000139437 |
| RefSeq Protein Accession(s) | NP_001137324.1 |
| RefSeq mRNA Accession(s) | NM_001143852.1, NM_032300.4, XM_011538836.2, XM_011538837.2 |
| UniProt ID(s) | Q9BT92 |
| UniGene ID(s) | Hs.410924 |
| HGNC ID(s) | HGNC:28135 |
| COSMIC ID Link(s) | TCHP |
| KEGG Gene ID(s) | hsa:84260 |
| PharmGKB ID(s) | PA143485629 |
| General Description of Recombinant Human Trichoplein keratin filament-binding protein Protein. | |
| Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a ‘capping’ or ‘branching’ protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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