PDF DatasheetHuman Acidic mammalian chitinase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Acidic mammalian chitinase based upon sequence from: Human
Isoform: Isoform 2
Host: QP8133 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Acidic mammalian chitinase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8133.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Ala368
Amino Acid Sequence: MVSTPENRQT FITSVIKFLR QYEFDGLDFD WEYPGSRGSP PQDKHLFTVL VQEMREAFEQ EAKQINKPRL MVTAAVAAGI SNIQSGYEIP QLSQYLDYIH VMTYDLHGSW EGYTGENSPL YKYPTDTGSN AYLNVDYVMN YWKDNGAPAE KLIVGFPTYG HNFILSNPSN TGIGAPTSGA GPAGPYAKES GIWAYYEICT FLKNGATQGW DAPQEVPYAY QGNVWVGYDN IKSFDIKAQW LKHNKFGGAM VWAIDLDDFT GTFCNQGKFP LISTLKKALG LQSASCTAPA QPIEPITAAP SGSGNGSGSS SSGGSSGGSG FCAVRANGLY PVANNRNAFW HCVNGVTYQQ NCQAGLVFDT SCDCCNWA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Acidic mammalian chitinase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Acidic mammalian chitinase Protein General Information | |
|---|---|
| Alternate Names | |
| TSA1902; AMCASE; CHIT2 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CHIA |
| Entrez Gene ID | 27159 |
| Ensemble Gene ID | ENSG00000134216 |
| RefSeq Protein Accession(s) | NP_001035713.1 |
| RefSeq mRNA Accession(s) | NM_001040623.2, NM_001258001.1, NM_001258002.1, NM_001258003.1, NM_001258004.1, NM_001258005.1, NM_021797.3, NM_201653.3, XM_006710577.3, XM_017001047.1, XM_017001048.1 |
| UniProt ID(s) | Q9BZP6 |
| UniGene ID(s) | Hs.128814 |
| HGNC ID(s) | HGNC:17432 |
| COSMIC ID Link(s) | CHIA |
| KEGG Gene ID(s) | hsa:27159 |
| PharmGKB ID(s) | PA142672117 |
| General Description of Recombinant Human Acidic mammalian chitinase Protein. | |
| Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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