PDF DatasheetHuman Endophilin-B1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Endophilin-B1 based upon sequence from: Human
Host: QP8147 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Endophilin-B1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8147.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn365
Amino Acid Sequence: MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE CTKIWTEKIM KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY MIDAGTEFGP GTAYGNALIK CGETQKRIGT ADRELIQTSA LNFLTPLRNF IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK KAKAAETRNS SEQELRITQS EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ CYQYMLDLQK QLGSFPSNYL SNNNQTSVTP VPSVLPNAIG SSAMASTSGL VITSPSNLSD LKECSGSRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG NQKGKVPITY LELLN
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Endophilin-B1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Endophilin-B1 Protein General Information | |
|---|---|
| Alternate Names | |
| CGI-61; Bif-1; PPP1R70; dJ612B15.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SH3GLB1 |
| Entrez Gene ID | 51100 |
| Ensemble Gene ID | ENSG00000097033 |
| RefSeq Protein Accession(s) | NP_001193580.1 |
| RefSeq mRNA Accession(s) | NM_001206651.1, NM_001206652.1, NM_001206653.1, NM_016009.4 |
| UniProt ID(s) | Q9Y371 |
| UniGene ID(s) | Hs.136309 |
| HGNC ID(s) | HGNC:10833 |
| COSMIC ID Link(s) | SH3GLB1 |
| KEGG Gene ID(s) | hsa:51100 |
| PharmGKB ID(s) | PA35739 |
| General Description of Recombinant Human Endophilin-B1 Protein. | |
| May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion . Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts . Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) ). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation . Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 . Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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