PDF DatasheetHuman Glutaredoxin-2, mitochondrial Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glutaredoxin-2, mitochondrial based upon sequence from: Human
Host: QP8154 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glutaredoxin-2, mitochondrial, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8154.
Bioactivity Data: Untested
Full Length? Full Length of BC028113
Expression Region: Met1 – Gln124
Amino Acid Sequence: MESNTSSSLE NLATAPVNQI QETISDNCVV IFSKTSCSYC TMAKKLFHDM NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL HKEGKLLPLV HQCYLKKSKR KEFQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Glutaredoxin-2, mitochondrial Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glutaredoxin-2, mitochondrial Protein General Information | |
|---|---|
| Alternate Names | |
| CGI-133; GRX2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GLRX2 |
| Entrez Gene ID | 51022 |
| Ensemble Gene ID | ENSG00000023572 |
| RefSeq Protein Accession(s) | NP_001230328.1 |
| RefSeq mRNA Accession(s) | NM_001243399.1, NM_001319291.1, NM_016066.4, NM_197962.2, XM_017001397.1 |
| UniProt ID(s) | Q9NS18 |
| UniGene ID(s) | Hs.458283 |
| HGNC ID(s) | HGNC:16065 |
| COSMIC ID Link(s) | GLRX2 |
| KEGG Gene ID(s) | hsa:51022 |
| PharmGKB ID(s) | PA28732 |
| General Description of Recombinant Human Glutaredoxin-2, mitochondrial Protein. | |
| Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.