PDF DatasheetHuman Transmembrane prolyl 4-hydroxylase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transmembrane prolyl 4-hydroxylase based upon sequence from: Human
Isoform: Isoform 3
Host: QP8156 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transmembrane prolyl 4-hydroxylase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8156.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 3
Expression Region: Val82 – Leu563
Amino Acid Sequence: VHYSNGDESS DPGPQHRAQG PGPEPTLGPL TRLEGIKVGH ERKVQLVTDR DHFIRTLSLK PLLFEIPGFL TDEECRLIIH LAQMKGLQRS QILPTEEYEE AMSTMQVSQL DLFRLLDQNR DGHLQLREVL AQTRLGNGWW MTPESIQEMY AAIKADPDGD GVLSLQEFSN MDLRDFHKYM RSHKAESSEL VRNSHHTWLY QGEGAHHIMR AIRQRVLRLT RLSPEIVELS EPLQVVRYGE GGHYHAHVDS GPVYPETICS HTKLVANESV PFETSCRQVS PNWGLPSILR PGTPMTQAQP CTVGVPLGMG PGDHWVIPVS PWEHPQLGTC SVPPLPYSYM TVLFYLNNVT GGGETVFPVA DNRTYDEMSL IQDDVDLRDT RRHCDKGNLR VKPQQGTAVF WYNYLPDGQG WVGDVDDYSL HGGCLVTRGT KWIANNWINV DPSRARQALF QQEMARLARE GGTDSQPEWA LDRAYRDARV EL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transmembrane prolyl 4-hydroxylase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transmembrane prolyl 4-hydroxylase Protein General Information | |
|---|---|
| Alternate Names | |
| P4H-TM; HIFPH4; PH-4; PH4; EGLN4; PHD4 | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | P4HTM |
| Entrez Gene ID | 54681 |
| Ensemble Gene ID | ENSG00000178467 |
| RefSeq Protein Accession(s) | NP_808807.2 |
| RefSeq mRNA Accession(s) | NM_177938.2, NM_177939.2 |
| UniProt ID(s) | Q9NXG6 |
| UniGene ID(s) | Hs.654944 |
| HGNC ID(s) | HGNC:28858 |
| COSMIC ID Link(s) | P4HTM |
| KEGG Gene ID(s) | hsa:54681 |
| PharmGKB ID(s) | PA164724295 |
| General Description of Recombinant Human Transmembrane prolyl 4-hydroxylase Protein. | |
| Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at ‘Pro-402’ and ‘Pro-564’. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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