PDF DatasheetHuman COP9 signalosome complex subunit 7a Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant COP9 signalosome complex subunit 7a based upon sequence from: Human
Host: QP8160 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) COP9 signalosome complex subunit 7a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8160.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Asn275
Amino Acid Sequence: SAEVKVTGQN QEQFLLLAKS AKGAALATLI HQVLEAPGVY VFGELLDMPN VRELAESDFA STFRLLTVFA YGTYADYLAE ARNLPPLTEA QKNKLRHLSV VTLAAKVKCI PYAVLLEALA LRNVRQLEDL VIEAVYADVL RGSLDQRNQR LEVDYSIGRD IQRQDLSAIA RTLQEWCVGC EVVLSGIEEQ VSRANQHKEQ QLGLKQQIES EVANLKKTIK VTTAAAAAAT SQDPEQHLTE LREPAPGTNQ RQPSKKASKG KGLRGSAKIW SKSN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human COP9 signalosome complex subunit 7a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human COP9 signalosome complex subunit 7a Protein General Information | |
|---|---|
| Alternate Names | |
| CSN7; SGN7a; CSN7A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COPS7A |
| Entrez Gene ID | 50813 |
| Ensemble Gene ID | ENSG00000111652 |
| RefSeq Protein Accession(s) | NP_001157565.1 |
| RefSeq mRNA Accession(s) | NM_001164093.1, NM_001164094.1, NM_001164095.2, NM_016319.3, XM_005253694.2 |
| UniProt ID(s) | Q9UBW8 |
| UniGene ID(s) | Hs.530823 |
| HGNC ID(s) | HGNC:16758 |
| COSMIC ID Link(s) | COPS7A |
| KEGG Gene ID(s) | hsa:50813 |
| PharmGKB ID(s) | PA26758 |
| General Description of Recombinant Human COP9 signalosome complex subunit 7a Protein. | |
| Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl syst, respectively. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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