PDF DatasheetHuman METTL11A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant METTL11A based upon sequence from: Human
Host: QP8164 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) METTL11A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8164.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg223
Amino Acid Sequence: MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ RFLREGPNKT GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA KTYLGEEGKR VRNYFCCGLQ DFTPEPDSYD VIWIQWVIGH LTDQHLAEFL RRCKGSLRPN GIIVIKDNMA QEGVILDDVD SSVCRDLDVV RRIICSAGLS LLAEERQENL PDEIYHVYSF ALR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human METTL11A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human METTL11A Protein General Information | |
|---|---|
| Alternate Names | |
| METTL11A; NTM1A; METTL11A; NRMT1; AD-003; HOMT1A; NRMT; C9orf32 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NTMT1 |
| Entrez Gene ID | 28989 |
| Ensemble Gene ID | ENSG00000148335 |
| RefSeq Protein Accession(s) | NP_001273725.1 |
| RefSeq mRNA Accession(s) | NM_001286796.1, NM_001286797.1, NM_001286798.1, NM_001286799.1, NM_001286800.1, NM_001286801.1, NM_001286802.1, NM_001286803.1, NM_014064.3 |
| UniProt ID(s) | Q9BV86 |
| UniGene ID(s) | Hs.744027 |
| HGNC ID(s) | HGNC:23373 |
| KEGG Gene ID(s) | hsa:28989 |
| PharmGKB ID(s) | PA162395788 |
| General Description of Recombinant Human METTL11A Protein. | |
| Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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