PDF DatasheetHuman IFIH1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant IFIH1 based upon sequence from: Human
Host: QP8166 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IFIH1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8166.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Lys700 – Asp1025
Amino Acid Sequence: KLTKLRNTIM EQYTRTEESA RGIIFTKTRQ SAYALSQWIT ENEKFAEVGV KAHHLIGAGH SSEFKPMTQN EQKEVISKFR TGKINLLIAT TVAEEGLDIK ECNIVIRYGL VTNEIAMVQA RGRARADEST YVLVAHSGSG VIEHETVNDF REKMMYKAIH CVQNMKPEEY AHKILELQMQ SIMEKKMKTK RNIAKHYKNN PSLITFLCKN CSVLACSGED IHVIEKMHHV NMTPEFKELY IVRENKALQK KCADYQINGE IICKCGQAWG TMMVHKGLDL PCLKIRNFVV VFKNNSTKKQ YKKWVELPIT FPNLDYSECC LFSDED
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IFIH1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IFIH1 Protein General Information | |
|---|---|
| Alternate Names | |
| AGS7; MDA-5; MDA5; RLR-2; IDDM19; Hlcd; SGMRT1; Interferon-induced helicase C domain-containing protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IFIH1 |
| Entrez Gene ID | 64135 |
| Ensemble Gene ID | ENSG00000115267 |
| RefSeq Protein Accession(s) | NP_071451.2 |
| RefSeq mRNA Accession(s) | NM_022168.3 |
| UniProt ID(s) | Q9BYX4 |
| UniGene ID(s) | Hs.163173 |
| HGNC ID(s) | HGNC:18873 |
| COSMIC ID Link(s) | IFIH1 |
| KEGG Gene ID(s) | hsa:64135 |
| PharmGKB ID(s) | PA134889215 |
| General Description of Recombinant Human IFIH1 Protein. | |
| Innate immune receptor which acts as a Cytoplasmic domain sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2′-O-methylation at their 5′ cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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