PDF DatasheetHuman E3 ubiquitin-protein ligase NRDP1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase NRDP1 based upon sequence from: Human
Host: QP8174 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase NRDP1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8174.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ile317
Amino Acid Sequence: MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC GLEMPKDELP NHNCIKHLRS VVQQQQTRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM VQEPGLVMIF AHGVEEI
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase NRDP1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase NRDP1 Protein General Information | |
|---|---|
| Alternate Names | |
| NRDP1; FLRF; SBBI03 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNF41 |
| Entrez Gene ID | 10193 |
| Ensemble Gene ID | ENSG00000181852 |
| RefSeq Protein Accession(s) | NP_001229755.1 |
| RefSeq mRNA Accession(s) | NM_001242826.1, NM_005785.3, NM_194358.2, NM_194359.2, XM_005268561.4, XM_011537734.2, XM_011537735.2 |
| UniProt ID(s) | Q9H4P4 |
| UniGene ID(s) | Hs.524502 |
| HGNC ID(s) | HGNC:18401 |
| COSMIC ID Link(s) | RNF41 |
| KEGG Gene ID(s) | hsa:10193 |
| PharmGKB ID(s) | PA134875033 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase NRDP1 Protein. | |
| Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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