PDF DatasheetHuman SAE1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SAE1 based upon sequence from: Human
Host: QP8183 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SAE1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8183.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys346
Amino Acid Sequence: MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SAE1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SAE1 Protein General Information | |
|---|---|
| Alternate Names | |
| SAE1; SUA1; UBLE1A; AOS1; HSPC140 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SAE1 |
| Entrez Gene ID | 10055 |
| Ensemble Gene ID | ENSG00000142230 |
| RefSeq Protein Accession(s) | NP_001139185.1 |
| RefSeq mRNA Accession(s) | NM_001145713.1, NM_001145714.1, NM_005500.2 |
| UniProt ID(s) | Q9UBE0 |
| UniGene ID(s) | Hs.515500 |
| HGNC ID(s) | HGNC:30660 |
| COSMIC ID Link(s) | SAE1 |
| KEGG Gene ID(s) | hsa:10055 |
| PharmGKB ID(s) | PA162402387 |
| General Description of Recombinant Human SAE1 Protein. | |
| The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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