PDF DatasheetHuman ASH2L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ASH2L based upon sequence from: Human
Isoform: Isoform 3
Host: QP8184 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ASH2L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8184.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 3
Expression Region: Met1 – Pro534
Amino Acid Sequence: MDTQAGSVDE ENGRQLGEVE LQCGICTKWF TADTFGIDTS SCLPFMTNYS FHCNVCHHSG NTYFLRKQAN LKEMCLSALA NLTWQSRTQD EHPKTMFSKD KDIIPFIDKY WECMTTRQRP GKMTWPNNIV KTMSKERDVF LVKEHPDPGS KDPEEDYPKF GLLDQDLSNI GPAYDNQKQS SAVSTSGNLN GGIAAGSSGK GRGAKRKQQD GGTTGTTKKA RSDPLFSAQR LPPHGYPLEH PFNKDGYRYI LAEPDPHAPD PEKLELDCWA GKPIPGDLYR ACLYERVLLA LHDRAPQLKI SDDRLTVVGE KGYSMVRASH GVRKGAWYFE ITVDEMPPDT AARLGWSQPL GNLQAPLGYD KFSYSWRSKK GTKFHQSIGK HYSSGYGQGD VLGFYINLPE DTETAKSLPD TYKDKALIKF KSYLYFEEKD FVDKAEKSLK QTPHSEIIFY KNGVNQGVAY KDIFEGVYFP AISLYKSCTV SINFGPCFKY PPKDLTYRPM SDMGWGAVVE HTLADVLYHV ETEVDGRRSP PWEP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ASH2L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ASH2L Protein General Information | |
|---|---|
| Alternate Names | |
| ASH2; ASH2L1; ASH2L2; Bre2; Set1/Ash2 histone methyltransferase complex subunit AS | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ASH2L |
| Entrez Gene ID | 9070 |
| Ensemble Gene ID | ENSG00000129691 |
| RefSeq Protein Accession(s) | NP_001098684.1 |
| RefSeq mRNA Accession(s) | NM_001105214.2, NM_001261832.1, NM_004674.4 |
| UniProt ID(s) | Q9UBL3 |
| UniGene ID(s) | Hs.521530 |
| HGNC ID(s) | HGNC:744 |
| COSMIC ID Link(s) | ASH2L |
| KEGG Gene ID(s) | hsa:9070 |
| PharmGKB ID(s) | PA25044 |
| General Description of Recombinant Human ASH2L Protein. | |
| Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ‘Lys-4’ of histone H3, but not if the neighboring ‘Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ‘Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hatopoiesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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