PDF DatasheetHuman Rab5 GDP / GTP exchange factor Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Rab5 GDP / GTP exchange factor based upon sequence from: Human
Isoform: Isoform 2
Host: QP8190 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Rab5 GDP/GTP exchange factor, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8190.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Gly491
Amino Acid Sequence: MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGSKKEIQEA KAPSPSINRQ TSIETDRVSK EFIEFLKTFH KTGQEIYKQT KLFLEGMHYK RDLSIEEQSE CAQDFYHNVA ERMQTRGKVP PERVEKIMDQ IEKYIMTRLY KYVFCPETTD DEKKDLAIQK RIRALRWVTP QMLCVPVNED IPEVSDMVVK AITDIIEMDS KRVPRDKLAC ITKCSKHIFN AIKITKNEPA SADDFLPTLI YIVLKGNPPR LQSNIQYITR FCNPSRLMTG EDGYYFTNLC CAVAFIEKLD AQSLNLSQED FDRYMSGQTS PRKQEAESWS PDACLGVKQM YKNLDLLSQL NERQERIMNE AKKLEKDLID WTDGIAREVQ DIVEKYPLEI KPPNQPLAAI DSENVENDKL PPPLQPQVYA G
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Rab5 GDP / GTP exchange factor Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Rab5 GDP / GTP exchange factor Protein General Information | |
|---|---|
| Alternate Names | |
| RAP1; rabex-5; RABEX5 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RABGEF1 |
| Entrez Gene ID | 27342 |
| Ensemble Gene ID | ENSG00000154710 |
| RefSeq Protein Accession(s) | NP_001273989.1 |
| RefSeq mRNA Accession(s) | NM_001287060.1, NM_001287061.1, NM_001287062.1, NM_014504.2 |
| UniProt ID(s) | Q9UJ41 |
| UniGene ID(s) | Hs.530053 |
| HGNC ID(s) | HGNC:17676 |
| COSMIC ID Link(s) | RABGEF1 |
| KEGG Gene ID(s) | hsa:27342 |
| PharmGKB ID(s) | PA134946532 |
| General Description of Recombinant Human Rab5 GDP / GTP exchange factor Protein. | |
| Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic mbrane fusion and mbrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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