PDF DatasheetHuman Cytokine-inducible SH2-containing protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cytokine-inducible SH2-containing protein based upon sequence from: Human
Host: QP8202 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cytokine-inducible SH2-containing protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8202.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC LPLPRRMADY LRQYPFQL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Cytokine-inducible SH2-containing protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cytokine-inducible SH2-containing protein Protein General Information | |
|---|---|
| Alternate Names | |
| CIS-1; G18; CIS; BACTS2; SOCS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CISH |
| Entrez Gene ID | 1154 |
| Ensemble Gene ID | ENSG00000114737 |
| RefSeq Protein Accession(s) | NP_037456.5 |
| RefSeq mRNA Accession(s) | NM_013324.5, NM_145071.2, XM_011533329.2 |
| UniProt ID(s) | Q9NSE2 |
| UniGene ID(s) | Hs.655334 |
| HGNC ID(s) | HGNC:1984 |
| COSMIC ID Link(s) | CISH |
| KEGG Gene ID(s) | hsa:1154 |
| PharmGKB ID(s) | PA26521 |
| General Description of Recombinant Human Cytokine-inducible SH2-containing protein Protein. | |
| SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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