PDF DatasheetHuman Homeobox protein NANOG Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Homeobox protein NANOG based upon sequence from: Human
Host: QP8217 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Homeobox protein NANOG, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8217.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val305
Amino Acid Sequence: MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL LIQDSPDSST SPKGKQPTSA EKSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS CMQFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM QPEDV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Homeobox protein NANOG Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Homeobox protein NANOG Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NANOG |
| Entrez Gene ID | 79923 |
| Ensemble Gene ID | ENSG00000111704 |
| RefSeq Protein Accession(s) | NP_001284627.1 |
| RefSeq mRNA Accession(s) | NM_001297698.1, NM_024865.3 |
| UniProt ID(s) | Q9H9S0 |
| UniGene ID(s) | Hs.635882 |
| HGNC ID(s) | HGNC:20857 |
| COSMIC ID Link(s) | NANOG |
| KEGG Gene ID(s) | hsa:79923 |
| PharmGKB ID(s) | PA134864904 |
| General Description of Recombinant Human Homeobox protein NANOG Protein. | |
| Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5′-TAAT[GT][GT]-3′ or 5′-[CG][GA][CG]C[GC]ATTAN[GC]-3′. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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