PDF DatasheetHuman Transcription factor 7-like 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcription factor 7-like 2 based upon sequence from: Human
Host: QP8221 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcription factor 7-like 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8221.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Thr456
Amino Acid Sequence: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETNE HSECFLNPCL SLPPIT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transcription factor 7-like 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transcription factor 7-like 2 Protein General Information | |
|---|---|
| Alternate Names | |
| TCF-4; TCF4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TCF7L2 |
| Entrez Gene ID | 6934 |
| Ensemble Gene ID | ENSG00000148737 |
| RefSeq Protein Accession(s) | NP_001139746.1 |
| RefSeq mRNA Accession(s) | NM_001146274.1, NM_001146283.1, NM_001146284.1, NM_001146286.1, NM_001198526.1, NM_001198528.1, NM_001198531.1, XM_005270084.1, XM_005270089.1, XM_005270096.2, XM_005270103.1, XM_017016592.1, XM_017016593.1 |
| UniProt ID(s) | Q9NQB0 |
| UniGene ID(s) | Hs.593995 |
| HGNC ID(s) | HGNC:11641 |
| COSMIC ID Link(s) | TCF7L2 |
| KEGG Gene ID(s) | hsa:6934 |
| PharmGKB ID(s) | PA36394 |
| General Description of Recombinant Human Transcription factor 7-like 2 Protein. | |
| Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5′-CCTTTGATC-3′ in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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