PDF DatasheetHuman Muscleblind-like protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Muscleblind-like protein 1 based upon sequence from: Human
Isoform: Isoform 5
Host: QP8222 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Muscleblind-like protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8222.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 5
Expression Region: Met1 – Met382
Amino Acid Sequence: MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV APSLATNASA AAFNPYLGPV SPSLVPAEIL PTAPMLVTGN PGVPVPAAAA AAAQKLMRTD RLEVCREYQR GNCNRGENDC RFAHPADSTM IDTNDNTVTV CMDYIKGRCS REKCKYFHPP AHLQAKIKAA QYQVNQAAAA QAAATAAAMG IPQAVLPPLP KRPALEKTNG ATAVFNTGIF QYQQALANMQ LQQHTAFLPP GSILCMTPAT SVVPMVHGAT PATVSAATTS ATSVPFAATA TANQIPIISA EHLTSHKYVT QM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Muscleblind-like protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Muscleblind-like protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| MBNL; EXP | |
| Molecular Weight | |
| Isoform 5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MBNL1 |
| Entrez Gene ID | 4154 |
| Ensemble Gene ID | ENSG00000152601 |
| RefSeq Protein Accession(s) | NP_001300986.1 |
| RefSeq mRNA Accession(s) | NM_001314057.1, NM_021038.4, NM_207292.2, NM_207293.1, NM_207294.1, NM_207295.1, NM_207296.1, NM_207297.1, XM_005247466.4, XM_005247471.4, XM_011512847.2, XM_011512849.2, XM_017006425.1, XM_017006426.1, XM_017006427.1, XM_017006428.1, XM_017006429.1, XM_017006430.1, XM_017006431.1, XM_017006436.1 |
| UniProt ID(s) | Q9NR56 |
| UniGene ID(s) | Hs.201858 |
| HGNC ID(s) | HGNC:6923 |
| COSMIC ID Link(s) | MBNL1 |
| KEGG Gene ID(s) | hsa:4154 |
| PharmGKB ID(s) | PA30666 |
| General Description of Recombinant Human Muscleblind-like protein 1 Protein. | |
| Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the st-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assbly. Binds to the 5′-YGCU(U/G)Y-3’consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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