PDF DatasheetHuman DNA dC->dU-editing enzyme APOBEC-3C Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA dC->dU-editing enzyme APOBEC-3C based upon sequence from: Human
Host: QP8223 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA dC->dU-editing enzyme APOBEC-3C, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8223.
Bioactivity Data: Untested
Full Length? Full Length of BC011739
Amino Acid Sequence: MNPQIRNPMK AMYPGTFYFQ FKNLWEANDR DETWLCFTVE GIKRRSVVSW KTGVFRNQVD SETHCHAERC FLSWFCDDIL SPNTKYQVTW YTSWSPCPDC AGEVAEFLAR HSNVNLTIFT ARLYYFQYPC YQEGLRSLSQ EGVAVEIMDY EDFKYCWENF VYNDNEPFKP WKGLKTNFRL LKRRLRESLQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DNA dC->dU-editing enzyme APOBEC-3C Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C Protein General Information | |
|---|---|
| Alternate Names | |
| ARDC2; ARDC4; ARP5; APOBEC1L; bK150C2.3; A3C; PBI | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | APOBEC3C |
| Entrez Gene ID | 27350 |
| Ensemble Gene ID | ENSG00000244509 |
| RefSeq Protein Accession(s) | NP_055323.2 |
| RefSeq mRNA Accession(s) | NM_014508.2 |
| UniProt ID(s) | Q9NRW3 |
| UniGene ID(s) | Hs.441124 |
| HGNC ID(s) | HGNC:17353 |
| COSMIC ID Link(s) | APOBEC3C |
| KEGG Gene ID(s) | hsa:27350 |
| PharmGKB ID(s) | PA24893 |
| General Description of Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C Protein. | |
| DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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