PDF DatasheetHuman E3 ubiquitin-protein ligase RAD18 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase RAD18 based upon sequence from: Human
Host: QP8224 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase RAD18, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8224.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn495
Amino Acid Sequence: MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI RKFLSYKTQC PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP AKSPASSSSK NLAVKVYTPV ASRQSLKQGS RLMDNFLIRE MSGSTSELLI KENKSKFSPQ KEASPAAKTK ETRSVEEIAP DPSEAKRPEP PSTSTLKQVT KVDCPVCGVN IPESHINKHL DSCLSREEKK ESLRSSVHKR KPLPKTVYNL LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQCD ALHPKSAAEI VREIENIEKT RMRLEASKLN ESVMVFTKDQ TEKEIDEIHS KYRKKHKSEF QLLVDQARKG YKKIAGMSQK TVTITKEDES TEKLSSVCMG QEDNMTSVTN HFSQSKLDSP EELEPDREED SSSCIDIQEV LSSSESDSCN SSSSDIIRDL LEEEEAWEAS HKNDLQDTEI SPRQNRRTRA AESAEIEPRN KRNRN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase RAD18 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase RAD18 Protein General Information | |
|---|---|
| Alternate Names | |
| RNF73 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAD18 |
| Entrez Gene ID | 56852 |
| Ensemble Gene ID | ENSG00000070950 |
| RefSeq Protein Accession(s) | NP_064550.3 |
| RefSeq mRNA Accession(s) | NM_020165.3 |
| UniProt ID(s) | Q9NS91 |
| UniGene ID(s) | Hs.375684 |
| HGNC ID(s) | HGNC:18278 |
| COSMIC ID Link(s) | RAD18 |
| KEGG Gene ID(s) | hsa:56852 |
| PharmGKB ID(s) | PA134912253 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase RAD18 Protein. | |
| E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on ‘Lys-164’. Has ssDNA binding activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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