PDF DatasheetRat ICOS / AILIM / CD278 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ICOS / AILIM / CD278 based upon sequence from: Rat
Host: QP8229 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) ICOS / AILIM / CD278, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8229.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Glu21 – Pro145
Amino Acid Sequence: ELNDLANHRM FSFHDGGVQI SCNYPETVQQ LKMQLFKDRE VLCDLTKTKG SGNTVSIKNP MSCPYQLSNN SVSFFLDNAD SSQGSYFLCS LSIFDPPPFQ EKNLSGGYLL IYESQLCCQL KLWLP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat ICOS / AILIM / CD278 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat ICOS / AILIM / CD278 Protein General Information | |
|---|---|
| Alternate Names | |
| ICOS; AILIM; CD278; CRP-1; H4; AILIM; CCLP; Ly115 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ICOS |
| Entrez Gene ID | 64545 |
| Ensemble Gene ID | ENSRNOG00000046196 |
| RefSeq Protein Accession(s) | NP_072132.1 |
| RefSeq mRNA Accession(s) | NM_022610.1, XM_006245037.3, XM_006245038.3, XM_008767136.2, XM_017596625.1 |
| UniProt ID(s) | Q9R1T7 |
| UniGene ID(s) | Rn.168816 |
| COSMIC ID Link(s) | ICOS |
| KEGG Gene ID(s) | rno:64545 |
| General Description of Recombinant Rat ICOS / AILIM / CD278 Protein. | |
| Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.