PDF DatasheetHuman Methionine synthase reductase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Methionine synthase reductase based upon sequence from: Human
Host: QP8231 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Methionine synthase reductase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8231.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser725
Amino Acid Sequence: MGAASVRAGA RLVEVALCSF TVTCLEVMRR FLLLYATQQG QAKAIAEEIC EQAVVHGFSA DLHCISESDK YDLKTETAPL VVVVSTTGTG DPPDTARKFV KEIQNQTLPV DFFAHLRYGL LGLGDSEYTY FCNGGKIIDK RLQELGARHF YDTGHADDCV GLELVVEPWI AGLWPALRKH FRSSRGQEEI SGALPVASPA SSRTDLVKSE LLHIESQVEL LRFDDSGRKD SEVLKQNAVN SNQSNVVIED FESSLTRSVP PLSQASLNIP GLPPEYLQVH LQESLGQEES QVSVTSADPV FQVPISKAVQ LTTNDAIKTT LLVELDISNT DFSYQPGDAF SVICPNSDSE VQSLLQRLQL EDKREHCVLL KIKADTKKKG ATLPQHIPAG CSLQFIFTWC LEIRAIPKKA FLRALVDYTS DSAEKRRLQE LCSKQGAADY SRFVRDACAC LLDLLLAFPS CQPPLSLLLE HLPKLQPRPY SCASSSLFHP GKLHFVFNIV EFLSTATTEV LRKGVCTGWL ALLVASVLQP NIHASHEDSG KALAPKISIS PRTTNSFHLP DDPSIPIIMV GPGTGIAPFI GFLQHREKLQ EQHPDGNFGA MWLFFGCRHK DRDYLFRKEL RHFLKHGILT HLKVSFSRDA PVGEEEAPAK YVQDNIQLHG QQVARILLQE NGHIYVCGDA KNMAKDVHDA LVQIISKEVG VEKLEAMKTL ATLKEEKRYL QDIWS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Methionine synthase reductase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Methionine synthase reductase Protein General Information | |
|---|---|
| Alternate Names | |
| MSR; cblE | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MTRR |
| Entrez Gene ID | 4552 |
| Ensemble Gene ID | ENSG00000124275 |
| RefSeq Protein Accession(s) | NP_002445.2 |
| RefSeq mRNA Accession(s) | NM_002454.2, NM_024010.2 |
| UniProt ID(s) | Q9UBK8 |
| UniGene ID(s) | Hs.481551 |
| HGNC ID(s) | HGNC:7473 |
| COSMIC ID Link(s) | MTRR |
| KEGG Gene ID(s) | hsa:4552 |
| PharmGKB ID(s) | PA31277 |
| General Description of Recombinant Human Methionine synthase reductase Protein. | |
| Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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