PDF DatasheetHuman E3 ubiquitin-protein ligase ZNRF3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase ZNRF3 based upon sequence from: Human
Host: QP8236 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase ZNRF3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8236.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Lys56 – Met219
Amino Acid Sequence: KETAFVEVVL FESSPSGDYT TYTTGLTGRF SRAGATLSAE GEIVQMHPLG LCNNNDEEDL YEYGWVGVVK LEQPELDPKP CLTVLGKAKR AVQRGATAVI FDVSENPEAI DQLNQGSEDP LKRPVVYVKG ADAIKLMNIV NKQKVARARI QHRPPRQPTE YFDM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase ZNRF3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase ZNRF3 Protein General Information | |
|---|---|
| Alternate Names | |
| RNF203; BK747E2.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ZNRF3 |
| Entrez Gene ID | 84133 |
| Ensemble Gene ID | ENSG00000183579 |
| RefSeq Protein Accession(s) | NP_001193927.1 |
| RefSeq mRNA Accession(s) | NM_001206998.1, NM_032173.3 |
| UniProt ID(s) | Q9ULT6 |
| UniGene ID(s) | Hs.604200 |
| HGNC ID(s) | HGNC:18126 |
| COSMIC ID Link(s) | ZNRF3 |
| KEGG Gene ID(s) | hsa:84133 |
| PharmGKB ID(s) | PA134983897 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase ZNRF3 Protein. | |
| E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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