PDF DatasheetHuman Syncytin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Syncytin-1 based upon sequence from: Human
Host: QP8241 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Syncytin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8241.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ala21 – Gln443
Amino Acid Sequence: APPPCRCMTS SSPYQEFLWR MQRPGNIDAP SYRSLSKGTP TFTAHTHMPR NCYHSATLCM HANTHYWTGK MINPSCPGGL GVTVCWTYFT QTGMSDGGGV QDQAREKHVK EVISQLTRVH GTSSPYKGLD LSKLHETLRT HTRLVSLFNT TLTGLHEVSA QNPTNCWICL PLNFRPYVSI PVPEQWNNFS TEINTTSVLV GPLVSNLEIT HTSNLTCVKF SNTTYTTNSQ CIRWVTPPTQ IVCLPSGIFF VCGTSAYRCL NGSSESMCFL SFLVPPMTIY TEQDLYSYVI SKPRNKRVPI LPFVIGAGVL GALGTGIGGI TTSTQFYYKL SQELNGDMER VADSLVTLQD QLNSLAAVVL QNRRALDLLT AERGGTCLFL GEECCYYVNQ SGIVTEKVKE IRDRIQRRAE ELRNTGPWGL LSQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Syncytin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Syncytin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| HERV-7q; ENVW; HERV7Q; ERVWE1; HERVW; ENV; HERV-W-ENV; HERVWENV | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ERVW-1 |
| Entrez Gene ID | 30816 |
| Ensemble Gene ID | ENSG00000242950 |
| RefSeq Protein Accession(s) | NP_001124397.1 |
| RefSeq mRNA Accession(s) | NM_001130925.1, NM_014590.3 |
| UniProt ID(s) | Q9UQF0 |
| HGNC ID(s) | HGNC:13525 |
| COSMIC ID Link(s) | ERVW-1 |
| KEGG Gene ID(s) | hsa:30816 |
| PharmGKB ID(s) | PA27878 |
| General Description of Recombinant Human Syncytin-1 Protein. | |
| This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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