PDF DatasheetHuman Ras-related protein Rab-23 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras-related protein Rab-23 based upon sequence from: Human
Host: QP8247 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras-related protein Rab-23, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8247.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Cys237
Amino Acid Sequence: MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSC
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ras-related protein Rab-23 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras-related protein Rab-23 Protein General Information | |
|---|---|
| Alternate Names | |
| HSPC137 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAB23 |
| Entrez Gene ID | 51715 |
| Ensemble Gene ID | ENSG00000112210 |
| RefSeq Protein Accession(s) | NP_001265595.1 |
| RefSeq mRNA Accession(s) | NM_001278666.1, NM_001278667.1, NM_001278668.1, NM_016277.4, NM_183227.2 |
| UniProt ID(s) | Q9ULC3 |
| UniGene ID(s) | Hs.555016 |
| HGNC ID(s) | HGNC:14263 |
| COSMIC ID Link(s) | RAB23 |
| KEGG Gene ID(s) | hsa:51715 |
| PharmGKB ID(s) | PA34113 |
| General Description of Recombinant Human Ras-related protein Rab-23 Protein. | |
| The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.