PDF DatasheetHuman Charged multivesicular body protein 2b Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Charged multivesicular body protein 2b based upon sequence from: Human
Host: QP8250 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Charged multivesicular body protein 2b, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8250.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala1 – Asp213
Amino Acid Sequence: ASLFKKKTVD DVIKEQNREL RGTQRAIIRD RAALEKQEKQ LELEIKKMAK IGNKEACKVL AKQLVHLRKQ KTRTFAVSSK VTSMSTQTKV MNSQMKMAGA MSTTAKTMQA VNKKMDPQKT LQTMQNFQKE NMKMEMTEEM INDTLDDIFD GSDDEEESQD IVNQVLDEIG IEISGKMAKA PSAARSLPSA STSKATISDE EIERQLKALG VD
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Charged multivesicular body protein 2b Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Charged multivesicular body protein 2b Protein General Information | |
|---|---|
| Alternate Names | |
| ALS17; DMT1; VPS2-2; CHMP2.5; VPS2B | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CHMP2B |
| Entrez Gene ID | 25978 |
| Ensemble Gene ID | ENSG00000083937 |
| RefSeq Protein Accession(s) | NP_001231573.1 |
| RefSeq mRNA Accession(s) | NM_001244644.1, NM_014043.3 |
| UniProt ID(s) | Q9UQN3 |
| UniGene ID(s) | Hs.476930 |
| HGNC ID(s) | HGNC:24537 |
| COSMIC ID Link(s) | CHMP2B |
| KEGG Gene ID(s) | hsa:25978 |
| PharmGKB ID(s) | PA142672112 |
| General Description of Recombinant Human Charged multivesicular body protein 2b Protein. | |
| Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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