PDF DatasheetHuman Fizzy-related protein homolog Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Fizzy-related protein homolog based upon sequence from: Human
Isoform: Isoform 2
Host: QP8256 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Fizzy-related protein homolog, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8256.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Arg493
Amino Acid Sequence: MDQDYERRLL RQIVIQNENT MPRVTEMRRT LTPASSPVSS PSKHGDRFIP SRAGANWSVN FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS TPEKKGLFTY SLSTKRSSPD DGNDVSPYSL SPVSNKSQKL LRSPRKPTRK ISKIPFKVLD APELQDDFYL NLVDWSSLNV LSVGLGTCVY LWSACTSQVT RLCDLSVEGD SVTSVGWSER GNLVAVGTHK GFVQIWDAAA GKKLSMLEGH TARVGALAWN AEQLSSGSRD RMILQRDIRT PPLQSERRLQ GHRQEVCGLK WSTDHQLLAS GGNDNKLLVW NHSSLSPVQQ YTEHLAAVKA IAWSPHQHGL LASGGGTADR CIRFWNTLTG QPLQCIDTGS QVCNLAWSKH ANELVSTHGY SQNQILVWKY PSLTQVAKLT GHSYRVLYLA MSPDGEAIVT GAGDETLRFW NVFSKTRSTK ESVSVLNLFT RIR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Fizzy-related protein homolog Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fizzy-related protein homolog Protein General Information | |
|---|---|
| Alternate Names | |
| FZR; FZR2; HCDH; CDH1; HCDH1; CDC20C | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FZR1 |
| Entrez Gene ID | 51343 |
| Ensemble Gene ID | ENSG00000105325 |
| RefSeq Protein Accession(s) | NP_001129669.1 |
| RefSeq mRNA Accession(s) | NM_001136197.1, NM_001136198.1, NM_016263.3, XM_005259573.4 |
| UniProt ID(s) | Q9UM11 |
| UniGene ID(s) | Hs.413133 |
| HGNC ID(s) | HGNC:24824 |
| COSMIC ID Link(s) | FZR1 |
| KEGG Gene ID(s) | hsa:51343 |
| PharmGKB ID(s) | PA134896003 |
| General Description of Recombinant Human Fizzy-related protein homolog Protein. | |
| Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacent of CDC20, and activates the APC/C during anaphase and telophase. The APC/C rains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate praturely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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