PDF DatasheetHuman STRAP Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant STRAP based upon sequence from: Human
Host: QP8281 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) STRAP, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8281.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala350
Amino Acid Sequence: MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL WCSEDKQILS ADDKTVRLWD HATMTEVKSL NFNMSVSSME YIPEGEILVI TYGRSIAFHS AVSLDPIKSF EAPATINSAS LHPEKEFLVA GGEDFKLYKY DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY GLWKCVLPEE DSGELAKPKI GFPETTEEEL EEIASENSDC IFPSAPDVKA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human STRAP Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human STRAP Protein General Information | |
|---|---|
| Alternate Names | |
| MAWD; PT-WD; UNRIP; Serine-threonine kinase receptor-associated prote | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | STRAP |
| Entrez Gene ID | 11171 |
| Ensemble Gene ID | ENSG00000023734 |
| RefSeq Protein Accession(s) | NP_009109.3 |
| RefSeq mRNA Accession(s) | NM_007178.3 |
| UniProt ID(s) | Q9Y3F4 |
| UniGene ID(s) | Hs.743971 |
| HGNC ID(s) | HGNC:30796 |
| COSMIC ID Link(s) | STRAP |
| KEGG Gene ID(s) | hsa:11171 |
| PharmGKB ID(s) | PA134867032 |
| General Description of Recombinant Human STRAP Protein. | |
| The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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