PDF DatasheetHuman Spindlin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Spindlin-1 based upon sequence from: Human
Host: QP8292 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Spindlin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8292.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser262
Amino Acid Sequence: MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP SVYFIKFDDD FHIYVYDLVK TS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Spindlin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Spindlin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| TDRD24; SPIN | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SPIN1 |
| Entrez Gene ID | 10927 |
| Ensemble Gene ID | ENSG00000106723 |
| RefSeq Protein Accession(s) | NP_006708.2 |
| RefSeq mRNA Accession(s) | NM_006717.2 |
| UniProt ID(s) | Q9Y657 |
| UniGene ID(s) | Hs.146804 |
| HGNC ID(s) | HGNC:11243 |
| COSMIC ID Link(s) | SPIN1 |
| KEGG Gene ID(s) | hsa:10927 |
| PharmGKB ID(s) | PA162404504 |
| General Description of Recombinant Human Spindlin-1 Protein. | |
| Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at ‘Lys-4’ and asymmetrically dimethylated at ‘Arg-8’ (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.