PDF DatasheetHuman Rho GDP-dissociation inhibitor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Rho GDP-dissociation inhibitor 1 based upon sequence from: Human
Host: QP8308 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Rho GDP-dissociation inhibitor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8308.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Asp204
Amino Acid Sequence: AEQEPTAEQL AQIAAENEED EHSVNYKPPA QKSIQEIQEL DKDDESLRKY KEALLGRVAV SADPNVPNVV VTGLTLVCSS APGPLELDLT GDLESFKKQS FVLKEGVEYR IKISFRVNRE IVSGMKYIQH TYRKGVKIDK TDYMVGSYGP RAEEYEFLTP VEEAPKGMLA RGSYSIKSRF TDDDKTDHLS WEWNLTIKKD WKD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Rho GDP-dissociation inhibitor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Rho GDP-dissociation inhibitor 1 Protein General Information | |
|---|---|
| Alternate Names | |
| HEL-S-47e; GDIA1; RHOGDI-1; RHOGDI; NPHS8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ARHGDIA |
| Entrez Gene ID | 396 |
| Ensemble Gene ID | ENSG00000141522 |
| RefSeq Protein Accession(s) | NP_001172006.1 |
| RefSeq mRNA Accession(s) | NM_001185077.2, NM_001185078.2, NM_001301240.1, NM_001301241.1, NM_001301242.1, NM_001301243.1, NM_004309.5 |
| UniProt ID(s) | P52565 |
| UniGene ID(s) | Hs.159161 |
| HGNC ID(s) | HGNC:678 |
| COSMIC ID Link(s) | ARHGDIA |
| KEGG Gene ID(s) | hsa:396 |
| PharmGKB ID(s) | PA24963 |
| General Description of Recombinant Human Rho GDP-dissociation inhibitor 1 Protein. | |
| Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from th, and the subsequent binding of GTP to th. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting th from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from mbranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SA5A and PLXNB3 that lead to inactivation of RAC1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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