PDF DatasheetHuman U1 small nuclear ribonucleoprotein A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant U1 small nuclear ribonucleoprotein A based upon sequence from: Human
Host: QP8341 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) U1 small nuclear ribonucleoprotein A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8341.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Pro8 – Ser278
Amino Acid Sequence: PNHTIYINNL NEKIKKDELK KSLYAIFSQF GQILDILVSR SLKMRGQAFV IFKEVSSATN ALRSMQGFPF YDKPMRIQYA KTDSDIIAKM KGTFVERDRK REKRKPKSQE TPATKKAVQG GGATPVVGAV QGPVPGMPPM TQAPRIMHHM PGQPPYMPPP GMIPPPGLAP GQIPPGAMPP QQLMPGQMPP AQPLSENPPN HILFLTNLPE ETNELMLSML FNQFPGFKEV RLVPGRHDIA FVEFDNEVQA GAARDALQGF KITQNNAMKI S
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human U1 small nuclear ribonucleoprotein A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human U1 small nuclear ribonucleoprotein A Protein General Information | |
|---|---|
| Alternate Names | |
| Mud1; U1A; U1-A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SNRPA |
| Entrez Gene ID | 6626 |
| Ensemble Gene ID | ENSG00000077312 |
| RefSeq Protein Accession(s) | NP_004587.1 |
| RefSeq mRNA Accession(s) | NM_004596.4 |
| UniProt ID(s) | P09012 |
| UniGene ID(s) | Hs.466775 |
| HGNC ID(s) | HGNC:11151 |
| COSMIC ID Link(s) | SNRPA |
| KEGG Gene ID(s) | hsa:6626 |
| PharmGKB ID(s) | PA35993 |
| General Description of Recombinant Human U1 small nuclear ribonucleoprotein A Protein. | |
| Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5′ splice-site and the subsequent assbly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds st loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5′-UGCAC-3′ motif on RNAs. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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