PDF DatasheetHuman Inosine-5′-monophosphate dehydrogenase 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Inosine-5′-monophosphate dehydrogenase 2 based upon sequence from: Human
Host: QP8353 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Inosine-5′-monophosphate dehydrogenase 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8353.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu5 – Phe514
Amino Acid Sequence: LISGGTSYVP DDGLTAQQLF NCGDGLTYND FLILPGYIDF TADQVDLTSA LTKKITLKTP LVSSPMDTVT EAGMAIAMAL TGGIGFIHHN CTPEFQANEV RKVKKYEQGF ITDPVVLSPK DRVRDVFEAK ARHGFCGIPI TDTGRMGSRL VGIISSRDID FLKEEEHDCF LEEIMTKRED LVVAPAGITL KEANEILQRS KKGKLPIVNE DDELVAIIAR TDLKKNRDYP LASKDAKKQL LCGAAIGTHE DDKYRLDLLA QAGVDVVVLD SSQGNSIFQI NMIKYIKDKY PNLQVIGGNV VTAAQAKNLI DAGVDALRVG MGSGSICITQ EVLACGRPQA TAVYKVSEYA RRFGVPVIAD GGIQNVGHIA KALALGASTV MMGSLLAATT EAPGEYFFSD GIRLKKYRGM GSLDAMDKHL SSQNRYFSEA DKIKVAQGVS GAVQDKGSIH KFVPYLIAGI QHSCQDIGAK SLTQVRAMMY SGELKFEKRT SSAQVEGGVH SLHSYEKRLF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Inosine-5′-monophosphate dehydrogenase 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Inosine-5′-monophosphate dehydrogenase 2 Protein General Information | |
|---|---|
| Alternate Names | |
| IMPD2; IMPDH-II | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IMPD2 |
| Entrez Gene ID | 3615 |
| Ensemble Gene ID | ENSG00000178035 |
| RefSeq Protein Accession(s) | NP_000875.2 |
| RefSeq mRNA Accession(s) | NM_000884.2 |
| UniProt ID(s) | P12268 |
| UniGene ID(s) | Hs.654400 |
| HGNC ID(s) | HGNC:6053 |
| KEGG Gene ID(s) | hsa:3615 |
| PharmGKB ID(s) | PA29863 |
| General Description of Recombinant Human Inosine-5′-monophosphate dehydrogenase 2 Protein. | |
| Catalyzes the conversion of inosine 5′-phosphate (IMP) to xanthosine 5′-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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