PDF DatasheetHuman Interferon-induced transmembrane protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Interferon-induced transmembrane protein 1 based upon sequence from: Human
Host: QP8354 protein expressed in E. coli.
Tag: N-terminal GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Interferon-induced transmembrane protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8354.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Met1 – His36
Amino Acid Sequence: MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Interferon-induced transmembrane protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Interferon-induced transmembrane protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| 9-27; DSPA2a; IFI17; CD225; LEU13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IFITM1 |
| Entrez Gene ID | 8519 |
| Ensemble Gene ID | ENSG00000185885 |
| RefSeq Protein Accession(s) | NP_003632.3 |
| RefSeq mRNA Accession(s) | NM_003641.3 |
| UniProt ID(s) | P13164 |
| UniGene ID(s) | Hs.458414 |
| HGNC ID(s) | HGNC:5412 |
| COSMIC ID Link(s) | IFITM1 |
| KEGG Gene ID(s) | hsa:8519 |
| PharmGKB ID(s) | PA29653 |
| General Description of Recombinant Human Interferon-induced transmembrane protein 1 Protein. | |
| IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.