PDF DatasheetHuman ADP-ribosylation factor-like protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ADP-ribosylation factor-like protein 2 based upon sequence from: Human
Host: QP8356 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ADP-ribosylation factor-like protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8356.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu19 – Asp184
Amino Acid Sequence: LLMLGLDNAG KTTILKKFNG EDIDTISPTL GFNIKTLEHR GFKLNIWDVG GQKSLRSYWR NYFESTDGLI WVVDSADRQR MQDCQRELQS LLVEERLAGA TLLIFANKQD LPGALSSNAI REVLELDSIR SHHWCIQGCS AVTGENLLPG IDWLLDDISS RIFTAD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ADP-ribosylation factor-like protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ADP-ribosylation factor-like protein 2 Protein General Information | |
|---|---|
| Alternate Names | |
| ARFL2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ARL2 |
| Entrez Gene ID | 402 |
| Ensemble Gene ID | ENSG00000213465 |
| RefSeq Protein Accession(s) | NP_001186674.1 |
| RefSeq mRNA Accession(s) | NM_001199745.1, NM_001667.3 |
| UniProt ID(s) | P36404 |
| UniGene ID(s) | Hs.502836 |
| HGNC ID(s) | HGNC:693 |
| COSMIC ID Link(s) | ARL2 |
| KEGG Gene ID(s) | hsa:402 |
| PharmGKB ID(s) | PA24986 |
| General Description of Recombinant Human ADP-ribosylation factor-like protein 2 Protein. | |
| Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassbly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassbly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca2+-dependent release of acetylcholine. Required for normal progress through the cell cycle. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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