PDF DatasheetHuman Dynein light chain 1, cytoplasmic Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Dynein light chain 1, cytoplasmic based upon sequence from: Human
Host: QP8357 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Dynein light chain 1, cytoplasmic, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8357.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gly89
Amino Acid Sequence: MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Dynein light chain 1, cytoplasmic Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Dynein light chain 1, cytoplasmic Protein General Information | |
|---|---|
| Alternate Names | |
| DNCLC1; LC8a; PIN; DLC1; DNCL1; hdlc1; DLC8; LC8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DYNLL1 |
| Entrez Gene ID | 8655 |
| Ensemble Gene ID | ENSG00000088986 |
| RefSeq Protein Accession(s) | NP_001032583.1 |
| RefSeq mRNA Accession(s) | NM_001037494.1, NM_001037495.1, NM_003746.2 |
| UniProt ID(s) | P63167 |
| UniGene ID(s) | Hs.5120 |
| HGNC ID(s) | HGNC:15476 |
| COSMIC ID Link(s) | DYNLL1 |
| KEGG Gene ID(s) | hsa:8655 |
| PharmGKB ID(s) | PA134972261 |
| General Description of Recombinant Human Dynein light chain 1, cytoplasmic Protein. | |
| Acts as one of several non-catalytic accessory components of the Cytoplasmic domain dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic domain dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from Cytoplasmic domain dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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