PDF DatasheetHuman Sorting nexin-3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Sorting nexin-3 based upon sequence from: Human
Host: QP8359 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Sorting nexin-3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8359.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Glu3 – Ala162
Amino Acid Sequence: ETVADTRRLI TKPQNLNDAY GPPSNFLEID VSNPQTVGVG RGRFTTYEIR VKTNLPIFKL KESTVRRRYS DFEWLRSELE RESKVVVPPL PGKAFLRQLP FRGDDGIFDD NFIEERKQGL EQFINKVAGH PLAQNERCLH MFLQDEIIDK SYTPSKIRHA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Sorting nexin-3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Sorting nexin-3 Protein General Information | |
|---|---|
| Alternate Names | |
| Grd19; MCOPS8; SDP3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SNX3 |
| Entrez Gene ID | 8724 |
| Ensemble Gene ID | ENSG00000112335 |
| RefSeq Protein Accession(s) | NP_001287858.1 |
| RefSeq mRNA Accession(s) | NM_001300929.1, NM_003795.5, NM_152827.3 |
| UniProt ID(s) | O60493 |
| UniGene ID(s) | Hs.12102 |
| HGNC ID(s) | HGNC:11174 |
| COSMIC ID Link(s) | SNX3 |
| KEGG Gene ID(s) | hsa:8724 |
| PharmGKB ID(s) | PA36013 |
| General Description of Recombinant Human Sorting nexin-3 Protein. | |
| Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) . Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome mbrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway . Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G . Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes . Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex . In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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