PDF DatasheetHuman ENSA / Endosulfine alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ENSA / Endosulfine alpha based upon sequence from: Human
Host: QP8383 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ENSA / Endosulfine alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8383.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu121
Amino Acid Sequence: MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ENSA / Endosulfine alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ENSA / Endosulfine alpha Protein General Information | |
|---|---|
| Alternate Names | |
| ENSA; Endosulfine alpha; ARPP-19e | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ENSA |
| Entrez Gene ID | 2029 |
| Ensemble Gene ID | ENSG00000143420 |
| RefSeq Protein Accession(s) | NP_004427.1 |
| RefSeq mRNA Accession(s) | NM_004436.2, NM_207042.1, NM_207043.1, NM_207044.1, NM_207045.1, NM_207046.1, NM_207047.1, NM_207168.1 |
| UniProt ID(s) | O43768 |
| UniGene ID(s) | Hs.632456 |
| HGNC ID(s) | HGNC:3360 |
| COSMIC ID Link(s) | ENSA |
| KEGG Gene ID(s) | hsa:2029 |
| PharmGKB ID(s) | PA27796 |
| General Description of Recombinant Human ENSA / Endosulfine alpha Protein. | |
| Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase . Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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