PDF DatasheetHuman ADAM15 / MDC15 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ADAM15 / MDC15 based upon sequence from: Human
Host: QP8390 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ADAM15 / MDC15, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8390.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Asp207 – Thr452
Amino Acid Sequence: DVVTETKTVE LVIVADHSEA QKYRDFQHLL NRTLEVALLL DTFFRPLNVR VALVGLEAWT QRDLVEISPN PAVTLENFLH WRRAHLLPRL PHDSAQLVTG TSFSGPTVGM AIQNSICSPD FSGGVNMDHS TSILGVASSI AHELGHSLGL DHDLPGNSCP CPGPAPAKTC IMEASTDFLP GLNFSNCSRR ALEKALLDGM GSCLFERLPS LPPMAAFCGN MFVEPGEQCD CGFLDDCVDP CCDSLT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ADAM15 / MDC15 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ADAM15 / MDC15 Protein General Information | |
|---|---|
| Alternate Names | |
| ADAM15; MDC15; AD56; MDC15 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ADAM15 |
| Entrez Gene ID | 8751 |
| Ensemble Gene ID | ENSG00000143537 |
| RefSeq Protein Accession(s) | NP_001248393.1 |
| RefSeq mRNA Accession(s) | NM_001261464.1, NM_001261465.1, NM_001261466.1, NM_003815.4, NM_207191.2, NM_207194.2, NM_207195.2, NM_207196.2, NM_207197.2 |
| UniProt ID(s) | Q13444 |
| UniGene ID(s) | Hs.312098 |
| HGNC ID(s) | HGNC:193 |
| COSMIC ID Link(s) | ADAM15 |
| KEGG Gene ID(s) | hsa:8751 |
| PharmGKB ID(s) | PA24510 |
| General Description of Recombinant Human ADAM15 / MDC15 Protein. | |
| Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage rodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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