Human FKBP12 / FKBP1A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant FKBP12 / FKBP1A based upon sequence from: Human
Host: QP8403 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) FKBP12 / FKBP1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8403.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly2 – Glu103
Amino Acid Sequence: GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKFDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human FKBP12 / FKBP1A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
Recombinant Human FKBP12 / FKBP1A Protein General Information | |
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Alternate Names | |
FKBP12; FKBP1A; PPIASE; FKBP12; PKCI2; FKBP1; PKC12; FKBP-12; FKBP-1A | |
Curated Database and Bioinformatic Data | |
Gene Symbol | FKBP1A |
Entrez Gene ID | 2280 |
Ensemble Gene ID | ENSG00000088832 |
RefSeq Protein Accession(s) | NP_000792.1 |
RefSeq mRNA Accession(s) | NM_000801.4, NM_054014.3 |
UniProt ID(s) | P62942 |
UniGene ID(s) | Hs.471933 |
HGNC ID(s) | HGNC:3711 |
COSMIC ID Link(s) | FKBP1A |
KEGG Gene ID(s) | hsa:2280 |
PharmGKB ID(s) | PA28153 |
General Description of Recombinant Human FKBP12 / FKBP1A Protein. | |
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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