PDF DatasheetHuman GM2A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GM2A based upon sequence from: Human
Host: QP8405 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GM2A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8405.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser32 – Ile193
Amino Acid Sequence: SSFSWDNCDE GKDPAVIRSL TLEPDPIIVP GNVTLSVMGS TSVPLSSPLK VDLVLEKEVA GLWIKIPCTD YIGSCTFEHF CDVLDMLIPT GEPCPEPLRT YGLPCHCPFK EGTYSLPKSE FVVPDLELPS WLTTGNYRIE SVLSSSGKRL GCIKIAASLK GI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GM2A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human GM2A Protein General Information | |
|---|---|
| Alternate Names | |
| GM2A; SAP-3; GM2-AP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GM2A |
| Entrez Gene ID | 2760 |
| Ensemble Gene ID | ENSG00000196743 |
| RefSeq Protein Accession(s) | NP_000396.2 |
| RefSeq mRNA Accession(s) | NM_000405.4 |
| UniProt ID(s) | P17900 |
| UniGene ID(s) | Hs.483873 |
| HGNC ID(s) | HGNC:4367 |
| COSMIC ID Link(s) | GM2A |
| KEGG Gene ID(s) | hsa:2760 |
| PharmGKB ID(s) | PA28752 |
| General Description of Recombinant Human GM2A Protein. | |
| The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity . Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from mbranes and presents th in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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