PDF DatasheetHuman Heterogeneous nuclear ribonucleoprotein D0 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Heterogeneous nuclear ribonucleoprotein D0 based upon sequence from: Human
Host: QP8416 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Heterogeneous nuclear ribonucleoprotein D0, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8416.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala18 – Tyr355
Amino Acid Sequence: AVGGSAGEQE GAMVAATQGA AAAAGSGAGT GGGTASGGTE GGSAESEGAK IDASKNEEDE GHSNSSPRHS EAATAQREEW KMFIGGLSWD TTKKDLKDYF SKFGEVVDCT LKLDPITGRS RGFGFVLFKE SESVDKVMDQ KEHKLNGKVI DPKRAKAMKT KEPVKKIFVG GLSPDTPEEK IREYFGGFGE VESIELPMDN KTNKRRGFCF ITFKEEEPVK KIMEKKYHNV GLSKCEIKVA MSKEQYQQQQ QWGSRGGFAG RARGRGGGPS QNWNQGYSNY WNQGYGNYGY NSQGYGGYGG YDYTGYNNYY GYGDYSNQQS GYGKVSRRGG HQNSYKPY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Heterogeneous nuclear ribonucleoprotein D0 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Heterogeneous nuclear ribonucleoprotein D0 Protein General Information | |
|---|---|
| Alternate Names | |
| P37; AUF1; AUF1A; HNRPD; hnRNPD0 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HNRPD |
| Entrez Gene ID | 3184 |
| Ensemble Gene ID | ENSG00000138668 |
| RefSeq Protein Accession(s) | NP_001003810.1 |
| RefSeq mRNA Accession(s) | NM_001003810.1, NM_002138.3, NM_031369.2, NM_031370.2 |
| UniProt ID(s) | Q14103 |
| UniGene ID(s) | Hs.480073 |
| HGNC ID(s) | HGNC:5036 |
| COSMIC ID Link(s) | HNRPD |
| KEGG Gene ID(s) | hsa:3184 |
| PharmGKB ID(s) | PA29361 |
| General Description of Recombinant Human Heterogeneous nuclear ribonucleoprotein D0 Protein. | |
| Binds with high affinity to RNA molecules that contain AU-rich elents (AREs) found within the 3′-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5′-UUAG-3′ sequence and also weaker to the single-stranded 5′-TTAGGG-3′ telomeric DNA repeat. Binds RNA oligonucleotides with 5′-UUAGGG-3′ repeats more tightly than the telomeric single-stranded DNA 5′-TTAGGG-3′ repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3’UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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