PDF DatasheetHuman Catechol O-methyltransferase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Catechol O-methyltransferase based upon sequence from: Human
Host: QP8420 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Catechol O-methyltransferase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8420.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly52 – Pro271
Amino Acid Sequence: GDTKEQRILN HVLQHAEPGN AQSVLEAIDT YCEQKEWAMN VGDKKGKIVD AVIQEHQPSV LLELGAYCGY SAVRMARLLS PGARLITIEI NPDCAAITQR MVDFAGVKDK VTLVVGASQD IIPQLKKKYD VDTLDMVFLD HWKDRYLPDT LLLEECGLLR KGTVLLADNV ICPGAPDFLA HVRGSSCFEC THYQSFLEYR EVVDGLEKAI YKGPGSEAGP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Catechol O-methyltransferase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Catechol O-methyltransferase Protein General Information | |
|---|---|
| Alternate Names | |
| HEL-S-98n | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COMT |
| Entrez Gene ID | 1312 |
| Ensemble Gene ID | ENSG00000093010 |
| RefSeq Protein Accession(s) | NP_000745.1 |
| RefSeq mRNA Accession(s) | NM_000754.3, NM_001135161.1, NM_001135162.1, NM_007310.2, XM_017028594.1, XM_017028595.1 |
| UniProt ID(s) | P21964 |
| UniGene ID(s) | Hs.370408 |
| HGNC ID(s) | HGNC:2228 |
| COSMIC ID Link(s) | COMT |
| KEGG Gene ID(s) | hsa:1312 |
| PharmGKB ID(s) | PA117 |
| General Description of Recombinant Human Catechol O-methyltransferase Protein. | |
| Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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