PDF DatasheetHuman NME1 / NDKA Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NME1 / NDKA based upon sequence from: Human
Host: QP8426 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NME1 / NDKA, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8426.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Glu152
Amino Acid Sequence: ANCERTFIAI KPDGVQRGLV GEIIKRFEQK GFRLVGLKFM QASEDLLKEH YVDLKDRPFF AGLVKYMHSG PVVAMVWEGL NVVKTGRVML GETNPADSKP GTIRGDFCIQ VGRNIIHGSD SVESAEKEIG LWFHPEELVD YTSCAQNWIY E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NME1 / NDKA Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NME1 / NDKA Protein General Information | |
|---|---|
| Alternate Names | |
| NME1; NDKA; GAAD; NB; AWD; NBS; NDPK-A; NDPKA; NDKA; NM23; NM23-H1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NME1 |
| Entrez Gene ID | 4830 |
| Ensemble Gene ID | ENSG00000239672 |
| RefSeq Protein Accession(s) | NP_000260.1 |
| RefSeq mRNA Accession(s) | NM_000269.2, NM_198175.1 |
| UniProt ID(s) | P15531 |
| UniGene ID(s) | Hs.463456 |
| HGNC ID(s) | HGNC:7849 |
| COSMIC ID Link(s) | NME1 |
| KEGG Gene ID(s) | hsa:4830 |
| PharmGKB ID(s) | PA249 |
| General Description of Recombinant Human NME1 / NDKA Protein. | |
| Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3′-5′ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 roves bases from the free 3′ end to enhance DNA damage and prevent DNA end reannealing and rapid repair. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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