PDF DatasheetHuman Thioredoxin / TXN / SASP Protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Thioredoxin / TXN / SASP Protein based upon sequence from: Human
Host: QP8427 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Thioredoxin / TXN / SASP Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8427.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Val2 – Val105
Amino Acid Sequence: VKQIESKTAF QEALDAAGDK LVVVDFSATW CGPCKMIKPF FHSLSEKYSN VIFLEVDVDD CQDVASECEV KCMPTFQFFK KGQKVGEFSG ANKEKLEATI NELV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Thioredoxin / TXN / SASP Protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Thioredoxin / TXN / SASP Protein Protein General Information | |
|---|---|
| Alternate Names | |
| Thioredoxin; TXN; SASP Protein; ADF; AW550880; Trx1; Txn | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TXN |
| Entrez Gene ID | 7295 |
| Ensemble Gene ID | ENSG00000136810 |
| RefSeq Protein Accession(s) | NP_001231867.1 |
| RefSeq mRNA Accession(s) | NM_001244938.1, NM_003329.3 |
| UniProt ID(s) | P10599 |
| UniGene ID(s) | Hs.435136 |
| HGNC ID(s) | HGNC:12435 |
| COSMIC ID Link(s) | TXN |
| KEGG Gene ID(s) | hsa:7295 |
| PharmGKB ID(s) | PA37091 |
| General Description of Recombinant Human Thioredoxin / TXN / SASP Protein Protein. | |
| Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.