PDF DatasheetHuman Homer protein homolog 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Homer protein homolog 1 based upon sequence from: Human
Host: QP8433 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Homer protein homolog 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8433.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser354
Amino Acid Sequence: MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Homer protein homolog 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Homer protein homolog 1 Protein General Information | |
|---|---|
| Alternate Names | |
| HOMER; HOMER1B; HOMER1C; HOMER1A; Ves-1; SYN47 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HOMER1 |
| Entrez Gene ID | 9456 |
| Ensemble Gene ID | ENSG00000152413 |
| RefSeq Protein Accession(s) | NP_001264006.1 |
| RefSeq mRNA Accession(s) | NM_001277077.1, NM_001277078.1, NM_004272.4 |
| UniProt ID(s) | Q86YM7 |
| UniGene ID(s) | Hs.591761 |
| HGNC ID(s) | HGNC:17512 |
| COSMIC ID Link(s) | HOMER1 |
| KEGG Gene ID(s) | hsa:9456 |
| PharmGKB ID(s) | PA134972608 |
| General Description of Recombinant Human Homer protein homolog 1 Protein. | |
| Postsynaptic density scaffolding protein. Binds and cross-links Cytoplasmic domain regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.