PDF DatasheetHuman Protein arginine N-methyltransferase 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein arginine N-methyltransferase 1 based upon sequence from: Human
Host: QP8434 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein arginine N-methyltransferase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8434.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Tyr248
Amino Acid Sequence: MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTNAC LIKEVDIY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein arginine N-methyltransferase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein arginine N-methyltransferase 1 Protein General Information | |
|---|---|
| Alternate Names | |
| HRMT1L2; ANM1; HCP1; IR1B4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PRMT1 |
| Entrez Gene ID | 3276 |
| Ensemble Gene ID | ENSG00000126457 |
| RefSeq Protein Accession(s) | NP_001527.3 |
| RefSeq mRNA Accession(s) | NM_001536.5, NM_198318.4, XM_017026734.1, XM_017026735.1 |
| UniProt ID(s) | Q99873 |
| UniGene ID(s) | Hs.20521 |
| HGNC ID(s) | HGNC:5187 |
| COSMIC ID Link(s) | PRMT1 |
| KEGG Gene ID(s) | hsa:3276 |
| PharmGKB ID(s) | PA29461 |
| General Description of Recombinant Human Protein arginine N-methyltransferase 1 Protein. | |
| Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 ‘Arg-4’ (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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