PDF DatasheetHuman Heterogeneous nuclear ribonucleoprotein Q Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Heterogeneous nuclear ribonucleoprotein Q based upon sequence from: Human
Host: QP8440 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Heterogeneous nuclear ribonucleoprotein Q, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8440.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala2 – Leu191
Amino Acid Sequence: ATEHVNGNGT EEPMDTTSAV IHSENFQTLL DAGLPQKVAE KLDEIYVAGL VAHSDLDERA IEALKEFNED GALAVLQQFK DSDLSHVQNK SAFLCGVMKT YRQREKQGTK VADSSKGPDE AKIKALLERT GYTLDVTTGQ RKYGGPPPDS VYSGQQPSVG TEIFVGKIPR DLFEDELVPL FEKAGPIWDL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Heterogeneous nuclear ribonucleoprotein Q Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Heterogeneous nuclear ribonucleoprotein Q Protein General Information | |
|---|---|
| Alternate Names | |
| GRY-RBP; HNRPQ1; PP68; hnRNP-Q; GRYRBP; NSAP1; HNRNPQ | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NSAP1 |
| Entrez Gene ID | 10492 |
| Ensemble Gene ID | ENSG00000135316 |
| RefSeq Protein Accession(s) | NP_001153145.1 |
| RefSeq mRNA Accession(s) | NM_001159673.1, NM_001159674.1, NM_001159675.1, NM_001159676.1, NM_001159677.1, NM_001253771.1, NM_006372.4, XM_005248637.2, XM_017010178.1 |
| UniProt ID(s) | O60506 |
| UniGene ID(s) | Hs.571177 |
| HGNC ID(s) | HGNC:16918 |
| KEGG Gene ID(s) | hsa:10492 |
| PharmGKB ID(s) | PA134985065 |
| General Description of Recombinant Human Heterogeneous nuclear ribonucleoprotein Q Protein. | |
| Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complentation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in Cytoplasmic domain vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assbles into the GAIT complex which binds to st loop-containing GAIT elents in the 3′-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; ses not to be essential for GAIT complex function. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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