PDF DatasheetHuman Polycomb complex protein BMI-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Polycomb complex protein BMI-1 based upon sequence from: Human
Host: QP8441 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Polycomb complex protein BMI-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8441.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Glu250
Amino Acid Sequence: MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD KEKSKEEVND KRYLRCPAAM TVMHLRKFLR SKMDIPNTFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR DGLTNAGELE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Polycomb complex protein BMI-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Polycomb complex protein BMI-1 Protein General Information | |
|---|---|
| Alternate Names | |
| FLVI2/BMI1; PCGF4; RNF51; flvi-2/bmi-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BMI1 |
| Entrez Gene ID | 100532731 |
| Ensemble Gene ID | ENSG00000168283 |
| RefSeq Protein Accession(s) | NP_001190991.1 |
| RefSeq mRNA Accession(s) | NM_001204062.1, NM_005180.8 |
| UniProt ID(s) | P35226 |
| UniGene ID(s) | Hs.380403 |
| HGNC ID(s) | HGNC:1066 |
| COSMIC ID Link(s) | BMI1 |
| KEGG Gene ID(s) | hsa:100532731 |
| PharmGKB ID(s) | PA25376 |
| General Description of Recombinant Human Polycomb complex protein BMI-1 Protein. | |
| Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin rodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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